Post​ Cardiopulmonary ​Bypass ​Changes in ​Liver ​Function

Post Cardiopulmonary Bypass Changes in Liver Function

This study examines abnormal LFT (mainly bilirubin) on postoperative day three as a predictor of open cardiac surgery mortality.1 Preoperative hyperbilirubinemia, high right atrial pressure, number of heart valves replaced and high blood transfusion requirements are risk factors predicting postoperative hyperbilirubinemia in 81% of all patients.2 This study strictly excluded high-risk condition...

Pupil changes during cardiopulmonary bypass.

Pupil diameter is used during anaesthesia to assess depth of anaesthesia and indicate cerebral hypoxia. This is especially so during cardiac bypass when other autonomic signs cannot be monitored. We have used a pupillometer to determine the effect of cardiopulmonary bypass on the pupil. We have also investigated if any effect was caused by washout of opioid from the central nervous system by al...

Post cardiopulmonary bypass bleeding: an introductory review.

Cardiac surgery requiring cardiopulmonary bypass (CPB) has increased in both number and safety over the past four decades. Postoperative bleeding continues to be a major cause of perioperative morbidity. The reported incidence varies from 4-32%. This paper reviews the preoperative evaluation and specific hemostasis defects associated with cardiac surgery and extracorporeal circulation. Monitori...

The platelet function defect of cardiopulmonary bypass.

The use of cardiopulmonary bypass (CPB) during cardiac surgery is associated with a hemostatic defect, the hallmark of which is a markedly prolonged bleeding time. However, the nature of the putative platelet function defect is controversial. In this study, blood was analyzed at 10 time points before, during, and after CPB. We used a whole-blood flow cytometric assay to study platelet surface g...

Platelet function defects related to cardiopulmonary bypass.